Host Factors Determine Early or Late Visible Manifestation of Mammary Carcinoma

Host factors determine early or late visible manifestation of mammary carcinoma Host factors determine visible carcinoma manifestation 19 Abstract Breast carcinoma growth depends on complex interactions of tumour characteristics and host predisposition factors. However, both in clinical practice and in spontaneous mouse cancer possibilities to determine the role of host contribution are limited. Therefore, we employed intact BLRB males as recipients of syngeneic spontaneous mammary carcinoma to study individual differences among intact male recipients. Blood samples were collected from 64 males. Two weeks later animals were inoculated with carcinoma cells. Mice bearing tumours with earlier and later visible manifestation constituted two different groups. Thirty haematological and serum biochemical parameters were compared for these groups. Only borderline differences were found in total protein content and in some parameters related to erythrocyte count. However, covariate matrices for the early and late emerging tumour groups differed significantly. Based on these findings and using artificial neural network software 14 informative parameters were selected as input to build a 4-layer perceptron architecture. Finally, mice belonging to early and late tumour emerging groups were recognized with a correct classification rate of 0.83 and AUC value of 0.99. Taken together, predisposition to a short or a long lag-period of carcinoma growth was present in the recipient hosts prior to tumour growth. Thus, routine laboratory clinical parameters, at least in mice, are somehow related to a complex hierarchy of intrinsic host predisposition factors. Taken together with reported precise predictive survival value of some laboratory parameters in renal cell carcinoma patients our findings provide a rationale to look for host related factors in the prognosis of breast cancer patients.